Selective beta1-blocker without its own sympathomimetic activity. Lowers intraocular pressure, expressed resorptive effect is minimal; does not cause miosis, spasm of accommodation by reducing aqueous humor production, night blindness, the effect of “the veil” in front of the eyes (unlike miotikov).
Typically, the onset of effect is observed within .30 minutes (the maximum effect develops within 2 hours), the duration – 24 h. The pharmacokinetics may be subject to systemic absorption. Communication with plasma proteins – 50%. The half-life (Tm) – 14 -. 22 hours excreted by the kidneys (15% unchanged). The permeability of the blood-brain barrier and the placental barrier – low secretion of breast milk -neznachitelnaya.
Open-angle glaucoma, a condition after laser trabeculoplasty, increased intraocular pressure.
Hypersensitivity, sinus bradycardia, atrioventricular block II-III degree, cardiogenic shock, decompensated chronic heart failure (also in history); Children up to age 18 years (effectiveness and safety are not defined). Precautions The drug should be used with caution while taking oral beta-blockers, as well as Raynaud’s syndrome, pheochromocytoma, diabetes, thyrotoxicosis.
Pregnancy and lactation
During pregnancy and lactation are used in cases where the benefits outweigh the risk of side effects.
Dosage and administration . Local Buried in the conjunctival sac of 1 drop 2 times a day; during the first month of treatment is performed under the control of intraocular pressure.
Side effects: Local reactions: allergic reactions, temporary discomfort in the eyes (tingling and burning sensation in the eye, watery eyes), transient blurred vision, foreign body sensation, itching, skin redness, conjunctivitis, keratitis, anisocoria, photophobia, decreased corneal sensitivity, “dry syndrome eyes “. Systemic reactions: insomnia, depressive neurosis, headache, rash, toxic epidermal necrolysis, bradycardia, hypotension, asthma, dyspnea.
If overdose, flush eyes with warm running water.
Interaction with other drugs
With simultaneous application of eye drops and beta-blockers in – risk of additive effects from both the intraocular pressure, and the manifestations of systemic effects of beta-blockers.
Drugs that suppress the deposition of catecholamines (reserpine), increase the risk of hypotension and / or bradycardia.
In the period of the drug should not wear contact lenses.
Do not affect the value of the pupil, with angle-closure glaucoma used only in conjunction with miotikami. When transferring a patient on dianabol pills after treatment with multiple antiglaucoma drugs last shall be progressively abolished. With insufficient reduction of intraocular pressure in conjunction with dianabol pills can use pilocarpine and other miotics, and / or epinephrine, and / or inhibitors karbangidrazy .. With prolonged use marked decrease in sensitivity to dianabol pills. During the period of treatment must be careful when driving and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Immediately after instillation of the drug can be a short-term loss of visual acuity, so the management of transport and work with mechanisms recommended not earlier than 15 minutes after the application of eye drops.
after instillation should immediately seal the bottle. Cardiovascular system requires special caution when treating patients with a history of conduction disturbances or heart failure. diabetes mellitus should be with extreme caution to beta-blockers to patients with spontaneous hypoglycemia or . patients with diabetes mellitus receiving insulin or oral hypoglycemic drugs as beta-blockers may mask the symptoms of acute hypoglycemia hyperthyroidism: beta-blockers may mask, so should not the symptoms of hyperthyroidism (tachycardia) cancel sharply them for suspected hyperthyroidism – may develop thyrotoxic crisis. The bodies of breath in patients with lung disease may asthma and other pulmonary complications in the treatment of dianabol pills. Surgery Before using general anesthesia should be gradually phased beta-blockers, as they reduce the ability of the heart to respond to the signals of the sympathetic nature. Muscle weakness beta-blockers are reinforce signs of muscle weakness, which are similar to the symptoms of myasthenia gravis (diplopia, ptosis, generalized weakness). The probability of allergic reactions Patients with a history of atopy or severe anaphylactic reaction to a variety of allergens, while taking beta adrenergic blocker may be more sensitive to repeated, accidental, diagnostic or therapeutic administration of the relevant allergens and unresponsive to the usual doses of epinephrine used to eliminate allergic reactions. cypionat 250
Pharmacological properties Cardioselective beta1-blocker, has no membrane stabilizing and intrinsic sympathomimetic activity. It has antihypertensive, antianginal and antiarrhythmic action. Blocking in low doses of beta1-adrenergic receptors of the heart, reduces the formation of catecholamines stimulated cAMP from ATP, reduces intracellular current ion calcium, adversely chrono, Dromo,, Butman-and inotropic effect (slows the heart rate (HR), depresses conduction and excitability, reducing myocardial contractility). Total peripheral vascular resistance at the beginning of the use of beta-blockers (in the first 24 hours after ingestion) increases (as a result of reciprocal increase in the activity of alpha-adrenoceptor stimulation and removal of beta2-adrenergic receptors), which after 1-3 days back to original, and with long-term appointment is reduced. The hypotensive effect associated with a decrease in minute volume of blood flow, decreased activity of the renin-angiotensin-aldosterone system (is more important for patients with initial hypersecretion of renin), the sensitivity of the baroreceptors of the aortic arch (not going to increase their activity in response to lowering blood pressure) and the influence of the central nervous system.The antihypertensive effect is a decrease in both systolic and diastolic blood pressure, decrease stroke and minute volume of blood. The average therapeutic doses has no effect on the tone of the peripheral arteries. Antihypertensive effect lasts for 24 hours, when taken regularly is stabilized by the end of 2 weeks of treatment. Antianginal effect is determined by a decrease in myocardial oxygen demand by reducing heart rate (diastole lengthening and improving myocardial perfusion) and contractility, as well as a decrease in the sensitivity of the myocardium to the effects of the sympathetic innervation. It slows heart rate at rest and during exercise. By increasing end-diastolic pressure in the left ventricle and increase the tension of the muscle fibers of the ventricles can increase oxygen demand, especially in patients with chronic heart failure. The antiarrhythmic effect due to the elimination of arrhythmogenic factors (tachycardia, increased activity of the sympathetic nervous system, increased cAMP levels, hypertension ), a decrease in the rate of spontaneous excitation of the sinus and ectopic pacemakers and slowing of atrioventricular conduction. Inhibition of pulses observed mainly in the antegrade and to a lesser extent in the retrograde direction through the atrioventricular node, and on additional routes. Increases the survival of patients with myocardial infarction (reduces the incidence of ventricular arrhythmias and angina attacks). In practice, does not weaken the bronchodilatory effect of isoprenaline. In contrast, nonselective beta-blockers when given in therapeutic doses, the average has a less pronounced effect on the organs containing beta2-adrenergic receptors (pancreas, skeletal muscle, smooth muscle of the peripheral arteries, bronchi and uterus), and carbohydrate metabolism; atherogenic action expression is not different from that of propranolol. To a lesser extent has negative BATM, chrono, foreign-and Dromotropic. When used in large doses (over 100 mg / day) has a blocking effect on both beta-adrenoceptor subtype. The negative chronotropic effect appears after 1 hour after administration, reaching its maximum after 2-4 hours and lasts up to 24 hours.
The absorption from the gastrointestinal tract – fast, incomplete (50-60%), the bioavailability – 40-50%, the solubility in fats is very low. Maximum concentration time – 2-4 hours. Poorly penetrates the blood-brain barrier, it passes through the placenta and breast milk. Contact with blood plasma proteins – 6-16%. Practically not metabolized in the liver. The half-life – 6-9 hours (increases in elderly patients).Excreted by the kidneys by glomerular filtration (85-100% unchanged). Impaired renal function accompanied by longer half-life and cumulation (necessary to decrease the dose) with creatinine clearance (CC) below 35 mL / min / 1.73 m². half-life of 16-27 hours, QC below 15 ml / min. – More than 27 hours, anuria extended to 144 hours. Displayed during hemodialysis.
- arterial hypertension;
- prevention of angina attacks, except Prinzmetal angina;
- cardiac arrhythmias: sinus tachycardia, supraventricular tachyarrhythmia prevention, ventricular arrythmia.
Hypersensitivity to the drug, cardiogenic shock, atrioventricular block P-PG degree, bradycardia (heart rate less than 40 bpm. / Min.), Sick sinus syndrome, sinoatrial block, congestive heart failure, or decompensated chronic heart failure, cardiomegaly without signs of chronic heart failure, Prinzmetal angina, hypotension (in the case of myocardial infarction, systolic blood pressure (BP) of less than 100 mm Hg), lactation, concomitant use of monoamine oxidase inhibitors (MAOIs), age 18 years (effectiveness and safety not installed).
1 diabetes and type 2 diabetes, metabolic acidosis, hypoglycemia, allergic reactions in the history of chronic obstructive pulmonary disease (including asthma, emphysema), chronic heart failure (compensated), obliterating peripheral vascular disease ( “intermittent” claudication Reynaud’s syndrome); pheochromocytoma, liver failure, chronic renal failure, myasthenia gravis, thyrotoxicosis, depression (including history), psoriasis, pregnancy, old age.
Pregnancy and lactation
If pregnancy should appoint Betakard ® only in cases where the benefit to the mother outweighs the potential risk to the fetus. Betakard ® is excreted in breast milk, so breastfeeding is contraindicated drug.
Dosing and Administration
Assign inside before a meal, do not chew, washed down with a small amount of liquid. Hypertension Treatment starts with 50 mg Betakard ® 1 time per day. To achieve a stable hypotensive effect requires 1-2 weeks of reception. With insufficient expression hypotensive effect dose was increased to 100 mg at one time. Further increase of the dose is not recommended, since it is not accompanied by increased clinical benefit. Angina The initial dose is 50 mg per day. If during the week is not an optimal therapeutic effect, increasing the dose to 100 mg per day. Elderly patients and patients with impaired renal excretory function requires correction dosing regime. In the presence of renal failure recommended dose correction according to the creatinine clearance. In patients with renal insufficiency with creatinine clearance values above 35 ml / min / 1.73 m 2 (normal range is 100-150 ml / min / 1,73m 2 ) a significant accumulation of the drug Betakard ® does not occur. The following maximum dose recommended for patients with renal insufficiency:
|Creatinine clearance (ml / min / 1.73 m 2 )||The half-life
|The maximum dose|
|15-35 for at least 15||16-27 more than 27||50 mg per day
of 100 mg a day
to 50 mg a day,
100 mg once in one day four
Patients who are on hemodialysis, Betakard® appoint 25 or 50 mg / day immediately after each dialysis session, which should be carried out under steady-state conditions, as there may be a drop in blood pressure.
In elderly patients, an initial single dose – 25 mg (may be increased under the control of blood pressure, heart rate).
Increasing the daily dose above 100 mg are not recommended because the therapeutic effect is not enhanced, and the likelihood of side effects increases.
On the part of the central nervous system : fatigue, weakness, dizziness, headache, drowsiness or insomnia, “nightmarish” dream, depression, anxiety, confusion, or momentary loss of memory, hallucinations, decreased ability to concentrate, decreased reaction rate, paresthesia in the extremities (in patients with “intermittent” claudication and Raynaud’s syndrome), myasthenia gravis, seizures.from the senses : visual disturbances, reduced secretion of tear fluid, dryness and soreness of eyes, conjunctivitis. On the part of the cardiovascular system : bradycardia, palpitations, conduction disturbances infarction, atrioventricular block (up to cardiac arrest), arrhythmia, weakening of the myocardial contractility and development (worsening) of chronic heart failure, orthostatic hypotension, symptoms vasoconstriction (cooling of the lower extremities, Raynaud’s syndrome), vasculitis, chest pain. digestive system : dryness of the oral mucosa, nausea, vomiting, abdominal pain, constipation or diarrhea, taste changes. The respiratory system : nasal congestion, difficulty breathing when administered at high doses (selectivity loss) and / or in predisposed patients – laryngo . – and bronchospasm part of the endocrine system .: hyperglycemia (in patients with type 2 diabetes), hypoglycemia (in patients receiving insulin), hypothyroid state Allergic reactions : itching, rash, urticaria. For the skin : increased sweating, flushing of the skin, exacerbation of psoriasis symptoms, psoriasis-like skin rash, reversible alopecia. Laboratory findings: thrombocytopenia (unusual bleeding and hemorrhage), agranulocytosis, leukopenia, increased activity of “liver” enzymes, hyperbilirubinemia. Effect on the fetus: intrauterine growth retardation, hypoglycemia, bradycardia. Other :. Back pain, arthralgia, weakening of libido, reduced potency, the syndrome of “lifting” (increasing angina attacks, increased blood pressure) The frequency of side effects increases with the dose.
Overdose Symptoms : bradycardia, dizziness, excessive reduction of blood pressure, fainting, arrhythmia, ventricular premature beats, atrioventricular block degree II-III, chronic heart failure, cyanosis of nails or palms, cramps, difficulty breathing, bronchospasm. Treatment : gastric lavage and the appointment of adsorbing drugs; in violation of atrioventricular conduction and / or bradycardia – in / in a 1-2 mg of atropine, epinephrine (adrenaline) or staging a temporary pacemaker; with ventricular arrhythmia – lidocaine (IA class of drugs does not apply); in lowering blood pressure – Patient should be in the Trendelenburg position. If there are no signs of pulmonary edema – in / plasma substituting solutions, with inefficiency – the introduction of epinephrine, dopamine, dobutamine; in chronic heart failure – cardiac glycosides, diuretics, glucagon; in convulsions – in / diazepam; with bronchospasm -ingalyatsionno or parenterally – beta adrenostimulyatorov. Perhaps dialysis.
Interaction with other drugs
allergens used for immunotherapy, or allergen extracts for skin tests increase the risk of severe systemic allergic reactions or anaphylaxis in patients treated with dianabol results.
Iodine-containing X-ray contrast agent for the on / in the increase the risk of anaphylactic reactions.
Phenytoin at / in the introduction, drugs for inhalation anesthesia (derivatives of hydrocarbons) increase the intensity of cardiodepressive action and the likelihood of lowering blood pressure.
When concomitant administration of insulin and hypoglycemic agents for oral masking the symptoms of developing hypoglycemia.
Reduces clearance of lidocaine and xanthine and increases their concentration in blood plasma , especially in patients with initially increased clearance of theophylline under the influence of smoking.
Antihypertensive effect of weakening non-steroidal anti-inflammatory drugs (delay of sodium ions and blockage of prostaglandin synthesis by the kidneys), corticosteroids, and estrogens (sodium retention).
Cardiac glycosides, methyldopa, reserpine and guanfacine blockers “slow “calcium channels (verapamil, diltiazem), amiodarone and other antiarrhythmic drugs increase the risk of developing or worsening heart failure, bradycardia, atrioventricular block and cardiac arrest. Diuretics, clonidine, sympatholytic, hydralazine, blockers “slow” calcium channel blockers and other antihypertensives may lead to an excessive reduction in blood pressure.
Extends the action of non-depolarizing muscle relaxants and anticoagulant effect of coumarin.
Tri- and tetracyclic antidepressants, antipsychotics (neuroleptics), ethanol, sedatives and hypnotics increase central nervous system depression.
not recommended simultaneous application with MAO inhibitors due to the significant increase in the hypotensive action, a break in treatment between receiving MAO inhibitors and dianabol results should not be less than 14 days.
Negidrirovannye ergot alkaloids increase the risk of peripheral circulatory disorders.
control for patients taking dianabol results should include monitoring of the heart rate (HR) and blood pressure (BP) (at the beginning of treatment – daily, then 1 every 3-4 months), the content of blood glucose in patients with diabetes 1 and type 2 (one every 4-5 months). In elderly patients, it is recommended to monitor renal function (1 every 4-5 months).
It is necessary to train the patient’s heart rate calculation method and instruct on the need of medical advice in heart rate less than 50 bpm. / Min. Approximately 20% of patients with angina Beta-blockers are ineffective.
The main reason – severe coronary atherosclerosis with a low threshold of ischemia (heart rate less than 100 beats / min.) And increased end-diastolic. the volume of the left ventricle that violate subendocardial blood flow. At the “smokers” the effectiveness of beta-blockers lower.
Patients who use contact lenses should bear in mind that during treatment may decrease the production of tear fluid.
When thyrotoxicosis dianabol results may mask certain clinical signs of hyperthyroidism (eg, tachycardia). Abrupt withdrawal in patients with thyrotoxicosis is contraindicated because the symptoms can increase.
In diabetes may mask tachycardia caused by hypoglycemia. In contrast, nonselective beta-blockers practically no increase insulin-induced hypoglycemia and delay recovery of blood glucose levels to the normal concentration.
At the same time taking clonidine its reception can be terminated only after a few days after discontinuation of dianabol results.
Perhaps the increased severity of the allergic reaction and no effect from the usual doses of epinephrine (adrenaline) with aggravated allergic history.
In just a few days before the general anesthesia with chloroform or diethyl ether is necessary to stop taking the drug. If the patient has taken the drug before surgery, he should pick up the drugs for general anesthesia with minimal negative inotropic effect.
Reciprocal activation n.vagus can eliminate I / atropine (1-2 mg). Drugs that reduce the reserves of catecholamines (eg, reserpine), may enhance the effect of beta-blockers, so patients taking such drug combinations should be under constant medical supervision in order to identify pronounced reduction in blood pressure and bradycardia.
The drug can be administered to patients with bronhospasticheskimi diseases in case of intolerance and / or ineffectiveness of other antihypertensive drugs, but should strictly follow the dosage. Overdosing is dangerous development of bronchospasm. In the case of elderly patients increasing bradycardia (less than 50 u. / Min.), Hypotension (systolic blood pressure below 100 mm Hg), atrioventricular block, bronchospasm, ventricular arrhythmias, severe liver and kidney function should be reduced dose or to discontinue treatment. It is recommended to discontinue therapy in the development of depression caused by the intake of beta-blockers.
Do not abruptly discontinue the treatment because of the risk of severe arrhythmias and myocardial infarction. Abolition are gradually reducing the dose for 2 weeks or more (reduce dose by 25% in 3-4 days).
It is necessary to cancel prior to the study in blood and urine catecholamines and Normetanephrine vanillylmandelic acid; titers of antinuclear antibodies (1-2 days).
During the period of treatment must be careful when driving and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Tablets, film-coated, 50 mg, 100 mg.
10 tablets in a blister made of aluminum foil and PVC film; . 3 blisters or 10 blisters with instruction for use in a cardboard box Sample not for sale : 10 tablets in a blister of aluminum foil and PVC film; 1 blister with instruction on use is packed in a cardboard box. cutbol
The properties of the drug Betaderm ® due to the combined effect of dianabol cycle and gentamicin.
dianabol cycle is a synthetic fluorinated derivatives of hydrocortisone, has a strong anti-inflammatory, antipruritic, anti-allergic and vasoconstrictor action. It reduces inflammation by inhibiting the production of prostaglandins and leukotrienes activity due to inhibition of phospholipase A 2 and reduce the release of arachidonic acid from phospholipids of cell membranes, and also has anti-allergic action. Due to the local vasoconstrictor action reduces exudative reaction.Accelerates protein biotransformation in the skin and weakens the proliferative processes.
Gentamicin belongs to the antibiotic of the aminoglycoside group, is active in respect of Streptococcus spp . (Group A – ß-hemolytic and alpha-hemolytic), of Staphylococcus spp . (Staphylococcus aureus – coagulase and coagulase and some strains producing penicillinase), Gram negative bacteria: Escherichia coli, Proteus spp., Pseudomonas aeruginosa and bacteria from the group of Klebsiella spp., Enter obacter spp., Serratia spp., Citrobacter spp., Salmonella spp. and Shigella spp.
Pharmacokinetics Absorption dianabol cycle easily penetrates the skin through the stratum corneum. Not biotransformation in the skin and penetrates therethrough into the body. dianabol cycle absorption through the skin is increased when applied to the skin in the area of soft folds when applying on the skin with a damaged epidermis or skin damaged by inflammation. Moreover, absorption is increased by the frequent use of a drug or after the application over a large surface of skin. Gentamicin after topical application to unbroken skin is not absorbed, and after application to the skin damaged by the pathological process, can be absorbed into the bloodstream. Metabolism dianabol cycle biotransformed principally in . hepatic excretion dianabol cycle as compounds with glucuronic acid and a small amount of unaltered mainly eliminated via the kidneys and in smaller amounts – in bile. Gentamicin not biotransformed in the body and excreted by the kidneys unchanged.
weeping, inflammatory condition of the skin (dermatitis), complicated by secondary bacterial infection occurring and with hyperkeratosis, pruritus:
- atopic dermatitis;
- seborrheic dermatitis;
- chronic simple lichen;
- allergic contact dermatitis;
- lupus erythematosus (skin manifestations);
- erythema multiforme.
- Hypersensitivity to the drug;
- viral and fungal infections of the skin;
- cutaneous manifestations of syphilis;
- pink and acne vulgaris;
- phlebitis and trophic ulcers;
- between vaccination and post-vaccination skin reactions;
- Children under 2 years old;
Precautions : atrophy of subcutaneous tissue in the elderly.
Pregnancy and lactation
Do not use in pregnant women. At the time of treatment should stop breastfeeding.
Dosage and administration:
Outwardly. Apply a small amount of the drug to the affected surface of the skin 1-2 times a day. Continuous use of the drug for a week should not exceed 45 g. duration of treatment depends on the efficacy and tolerability, and is usually no more than 2-4 weeks.
Very rarely when using the drug Betaderm ® observed: burning sensation, erythema, exudation, pigmentation disorders and itchy.
There may be: acne, steroid purpura, inhibition of epidermal growth, atrophy of subcutaneous fat, dry skin, depigmentation or hyperpigmentation of the skin, skin atrophy and striae, telangiectasia, folliculitis.Sometimes it may appear urticaria or maculopapular rash.
Prolonged use or when applied to large surface possible systemic side effects characteristic of glucocorticosteroids (suppression of adrenocortical function, weight gain, osteoporosis, high blood pressure, edema, ulceration of the mucous membrane of the gastrointestinal intestinal tract, exacerbation of latent foci of infection, hyperkalemia, agitation, insomnia, menstrual disorders).
after application on the facial skin, the drug may cause perioral dermatitis, and after application to the skin age can sometimes cause increasing incidence of glaucoma or accelerate the development of cataracts. Moreover, given the content of gentamicin ototoxicity symptoms may occur when the drug is applied to the mucous membranes or substantial surface of the skin, particularly the damaged pathological process.
In children (side effects are in addition to side effects in adults) – inhibition of the hypothalamic-pituitary -nadpochechnikovoy system, Cushing’s syndrome, growth retardation, retarded weight gain, increased intracranial pressure (dianabol cycle).
Overdose is rarely observed. However, with prolonged use, and the use of local corticosteroids over a large surface possible adrenal suppression with the development of secondary adrenal insufficiency and Cushing’s symptoms, including Cushing’s syndrome. An overdose of gentamicin may lead to an increase in non-sensitive flora. Treatment: Symptomatic. Acute symptoms of Cushing’s usually reversible.Electrolyte balance correction is performed, if necessary.
Interaction with other drugs
The drug may increase the effects of immunosuppressive agents, and weaken the effect of immunostimulatory drugs.
is necessary to avoid long-term use, as this increases the frequency of occurrence of side effects and may develop bacterial resistance to gentamicin.
Do not use the drug on the skin of a person in connection with the appearance of telangiectasia, even after a short use.
Avoid contact Betaderm drug ® in eyes and periorbital region.
Some areas of the body (inguinal folds, armpits and perianal region) are more exposed to risk of stretch marks. Therefore, the duration of the drug should be limited to these areas.
With prolonged use Betaderm drug ® on large areas of skin with impaired integrity there is a potential absorption of gentamicin and, accordingly, the development of the symptoms of ototoxicity.
Do not use the drug under an occlusive dressing.
If there is an urgent need for overlay bandages, you should put a bandage, breathable and does not use a seal, oilcloth bandages.
In cases of fungal superinfection requires additional use of an antifungal drug. Children. Children are allowed use of the drug with two years only on strict conditions and under the supervision of a physician.due to the fact that the children area of the skin in relation to body weight is greater and underdeveloped epidermis with topical drug absorption may proportionally larger amounts of the active ingredients and, therefore, there is a greater risk of systemic side effects. Apply the medication in children should be as soon as possible and in compliance with all precautionary measures.
Effects on ability to drive vehicles and mechanisms of
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An antagonist of H 1 of the inner ear vascular histamine receptor antagonist H 3 histamine receptors of the vestibular nuclei of the central nervous system (CNS). Due to relaxation of precapillary sphincters of the inner ear blood vessels improves blood circulation in the vascular strip of the inner ear. Dose-dependently reduced the generation of action potentials in the neurons of the lateral and medial vestibular nuclei. It accelerates the recovery of vestibular function after unilateral vestibular neyrektomii, accelerating and facilitating central vestibular compensation (due to antagonism with H 3 histamine receptors). It eases symptoms of the syndrome of Meniere and vestibular vertigo. Stable therapeutic effect after 14 days.
Absorbed quickly bond to plasma proteins – low, less than 5%. The maximum plasma concentration (C max ) reached after 1 hour. It is metabolized to inactive metabolites: 2-pyridylacetic acid (the main metabolite) and demetilbetagistina. Almost completely (85-90%), kidneys displayed as a metabolite of (2-peridiluksusnoy acid) for 24 hours. Elimination of dianabol for sale and demetilbetagistina kidneys slightly.Bowel displayed only a small part of dianabol for sale and its metabolites.
Indications for use:
Treatment of Meniere’s syndrome, which is characterized by dizziness (accompanied by nausea and vomiting), hearing loss and tinnitus. Symptomatic treatment of vestibular vertigo (vertigo).
Contraindications for use:
Hypersensitivity to one of the components of the drug, children under 18 years (due to lack of data), pregnancy, lactation.
Peptic ulcer and 12 duodenal ulcer (in history), feohromitsitoma, bronchial asthma.
Pregnancy and lactation:
The drug is contraindicated during pregnancy because not enough data to assess the impact of the drug on pregnant women and the fetus. During lactation the drug should not be used or at the time of treatment should stop breastfeeding.
Dosage and administration:
Inside, during a meal.
8 mg Tablets: 1-2 tablets three times a day.
16 mg tablets: 2.1 – 1 tablet 3 times daily.
24 mg tablet: 1 tablet 2 times a day.
The course of treatment is determined individually. Improvement usually noted early in therapy, a therapeutic effect is stable after two weeks of treatment and may increase for a few months of treatment.Treatment long. The duration of the drug is chosen individually.
Frequency: often – more than 1/100 and less than 1/10.
From the digestive system: often – nausea, dyspepsia.
Allergic reactions : hypersensitivity (including anaphylaxis, angioedema, rash, urticaria, angioedema).
From the digestive system: vomiting, abdomenalnaya pain, bloating.
For the skin: itching.
Symptoms: nausea, vomiting, abdominal pain, drowsiness (while taking a dose up to 640 mg); convulsions, cardiopulmonary complications (when receiving a dose of 640 mg or more in combination with other drugs (drug).
Treatment: gastric lavage, activated charcoal, symptomatic therapy.
Interaction with other drugs: Cases interaction or incompatibility with other drugs are unknown.
The therapeutic effect in some cases increases during several months of starting treatment.
Effects on ability to drive a car or other mechanical means
dianabol for sale does not have a sedative effect and does not affect the ability to drive a car or work on the machines and mechanisms.
Tablets 8, 16, 24 mg.
At 5, 7, 10, 14, 15, 20, 30 tablets in blisters of PVC film and aluminum foil printed patent.
Betagenot is a combination drug containing a synthetic glucocorticosteroid betamethasone and dianabol antibiotic of the aminoglycoside. Betagenot has anti-inflammatory and anti-allergic effect. dianabol – a broad spectrum antibiotic of the aminoglycoside, bactericidal effect. Effective against: Staphylococcus aureus (coagulase positive, coagulase and some strains producing penicillinase), Pseudomonas acruginosa, indolpolozhitelnyh and indolotritsatelnyh species Proteus, Escherichia coli, Klebsiella pneumoniae; Hemophilus influenzae, Hemophilus aegyptius, Aerobacter atrogenes, Moraxella lacunata (stick-Moraksa Aksenfeld) and types Nesseria, including Nesseria gonorrhoeas.
Betamethasone – glucocorticosteroid, it has a local anti-inflammatory, vasoconstrictor, anti-allergic effect. It stops the release of cytokines and inflammatory mediators. It reduces the metabolism of arachidonic acid, induces lipokortinov, has anti-edematous activity.
The drug penetrates into the aqueous humor, cornea, iris, ciliary body, the retina. Can exert a systemic effect only when used in higher doses or prolonged use.
Indications for use.
- Allergic processes and anterior eye infections caused by sensitive to dianabol microflora (conjunctivitis, keratitis, blepharitis, barley);
- prevention and treatment of inflammatory events in the postoperative period (cataract,
Diseases of the ear:
- Treatment of allergic otitis externa;
- infectious otitis media caused by susceptible to dianabol microflora except viral otitis;
- chronic eczematous external otitis;
- seborrheic otitis externa;
- chronic diseases of the external ear canal skin caused by Lichen simplex.
The drug is contraindicated in the following diseases and conditions:
- Hypersensitivity to betamethasone, dianabol or other ingredients;
- fungal eye;
- acute viral diseases of the eye, including acute superficial keratitis caused by Herpes simplex;
- tubercular eye disease;
- thinning or a defect of the corneal epithelium, the sclera, glaucoma;
- children’s age, the lactation period;
- fungal infections of the skin of the outer ear canal;
- ear tuberculous lesion;
- acute viral disease of the ear;
- the presence of chronic suffering or prior otitis media;
- violation of the integrity of the tympanic membrane (development of ototoxicity).
As with the rest receiving glucocorticoid and mineralocorticoid, care must be taken in cases of cardiac, renal, hepatic insufficiency, arterial hypertension, nephrolithiasis.
In addition, caution in diabetes, high myopia, open-angle glaucoma.
Dosing and Administration
The dosage is determined individually.
Eye Disorders:. Topically in the conjunctival sac 1-2 drops of the drug solution 4-6 times a day,
ear diseases: topically in the ear canal by 3-4 drops of solution every 2-3 hours. After achieving the desired effect, it is necessary to gradually reduce the multiplicity of the drug to the desired, providing control over the symptoms of the disease.
Very rarely there may be adverse reactions from the organs of vision:
- thinning or perforation of the cornea, sclera;
- increased intraocular pressure;
- posterior subcapsular cataract formation;
- secondary infection, the spread of Herpes simplex;
- burning sensation, visual field loss, acute anterior uveitis, mydriasis, accommodation paresis, ptosis (betamethasone), allergic reactions (dianabol);
From the hearing: a burning sensation, pain and tingling in the ear, dermatitis of the external auditory canal.
During the use of the drug should regularly check the intraocular pressure, the state of the lens, as long-term therapy may develop steroid glaucoma and cataracts.
If you use contact lenses need to be removed before instillation of the drug, and can be worn after 15 minutes. Since a few minutes may be reduced after instillation of the drug, you should be careful when operating machinery and driving.
Pregnancy and lactation:
Do not use during pregnancy and lactation. Running low dose t3 clen cycle trying to lose bodyfat isn’t a real hot idea imo.