The properties of the drug Betaderm ® due to the combined effect of dianabol cycle and gentamicin.
dianabol cycle is a synthetic fluorinated derivatives of hydrocortisone, has a strong anti-inflammatory, antipruritic, anti-allergic and vasoconstrictor action. It reduces inflammation by inhibiting the production of prostaglandins and leukotrienes activity due to inhibition of phospholipase A 2 and reduce the release of arachidonic acid from phospholipids of cell membranes, and also has anti-allergic action. Due to the local vasoconstrictor action reduces exudative reaction.Accelerates protein biotransformation in the skin and weakens the proliferative processes.
Gentamicin belongs to the antibiotic of the aminoglycoside group, is active in respect of Streptococcus spp . (Group A – ß-hemolytic and alpha-hemolytic), of Staphylococcus spp . (Staphylococcus aureus – coagulase and coagulase and some strains producing penicillinase), Gram negative bacteria: Escherichia coli, Proteus spp., Pseudomonas aeruginosa and bacteria from the group of Klebsiella spp., Enter obacter spp., Serratia spp., Citrobacter spp., Salmonella spp. and Shigella spp.
Pharmacokinetics Absorption dianabol cycle easily penetrates the skin through the stratum corneum. Not biotransformation in the skin and penetrates therethrough into the body. dianabol cycle absorption through the skin is increased when applied to the skin in the area of soft folds when applying on the skin with a damaged epidermis or skin damaged by inflammation. Moreover, absorption is increased by the frequent use of a drug or after the application over a large surface of skin. Gentamicin after topical application to unbroken skin is not absorbed, and after application to the skin damaged by the pathological process, can be absorbed into the bloodstream. Metabolism dianabol cycle biotransformed principally in . hepatic excretion dianabol cycle as compounds with glucuronic acid and a small amount of unaltered mainly eliminated via the kidneys and in smaller amounts – in bile. Gentamicin not biotransformed in the body and excreted by the kidneys unchanged.
weeping, inflammatory condition of the skin (dermatitis), complicated by secondary bacterial infection occurring and with hyperkeratosis, pruritus:
- atopic dermatitis;
- seborrheic dermatitis;
- chronic simple lichen;
- allergic contact dermatitis;
- lupus erythematosus (skin manifestations);
- erythema multiforme.
- Hypersensitivity to the drug;
- viral and fungal infections of the skin;
- cutaneous manifestations of syphilis;
- pink and acne vulgaris;
- phlebitis and trophic ulcers;
- between vaccination and post-vaccination skin reactions;
- Children under 2 years old;
Precautions : atrophy of subcutaneous tissue in the elderly.
Pregnancy and lactation
Do not use in pregnant women. At the time of treatment should stop breastfeeding.
Dosage and administration:
Outwardly. Apply a small amount of the drug to the affected surface of the skin 1-2 times a day. Continuous use of the drug for a week should not exceed 45 g. duration of treatment depends on the efficacy and tolerability, and is usually no more than 2-4 weeks.
Very rarely when using the drug Betaderm ® observed: burning sensation, erythema, exudation, pigmentation disorders and itchy.
There may be: acne, steroid purpura, inhibition of epidermal growth, atrophy of subcutaneous fat, dry skin, depigmentation or hyperpigmentation of the skin, skin atrophy and striae, telangiectasia, folliculitis.Sometimes it may appear urticaria or maculopapular rash.
Prolonged use or when applied to large surface possible systemic side effects characteristic of glucocorticosteroids (suppression of adrenocortical function, weight gain, osteoporosis, high blood pressure, edema, ulceration of the mucous membrane of the gastrointestinal intestinal tract, exacerbation of latent foci of infection, hyperkalemia, agitation, insomnia, menstrual disorders).
after application on the facial skin, the drug may cause perioral dermatitis, and after application to the skin age can sometimes cause increasing incidence of glaucoma or accelerate the development of cataracts. Moreover, given the content of gentamicin ototoxicity symptoms may occur when the drug is applied to the mucous membranes or substantial surface of the skin, particularly the damaged pathological process.
In children (side effects are in addition to side effects in adults) – inhibition of the hypothalamic-pituitary -nadpochechnikovoy system, Cushing’s syndrome, growth retardation, retarded weight gain, increased intracranial pressure (dianabol cycle).
Overdose is rarely observed. However, with prolonged use, and the use of local corticosteroids over a large surface possible adrenal suppression with the development of secondary adrenal insufficiency and Cushing’s symptoms, including Cushing’s syndrome. An overdose of gentamicin may lead to an increase in non-sensitive flora. Treatment: Symptomatic. Acute symptoms of Cushing’s usually reversible.Electrolyte balance correction is performed, if necessary.
Interaction with other drugs
The drug may increase the effects of immunosuppressive agents, and weaken the effect of immunostimulatory drugs.
is necessary to avoid long-term use, as this increases the frequency of occurrence of side effects and may develop bacterial resistance to gentamicin.
Do not use the drug on the skin of a person in connection with the appearance of telangiectasia, even after a short use.
Avoid contact Betaderm drug ® in eyes and periorbital region.
Some areas of the body (inguinal folds, armpits and perianal region) are more exposed to risk of stretch marks. Therefore, the duration of the drug should be limited to these areas.
With prolonged use Betaderm drug ® on large areas of skin with impaired integrity there is a potential absorption of gentamicin and, accordingly, the development of the symptoms of ototoxicity.
Do not use the drug under an occlusive dressing.
If there is an urgent need for overlay bandages, you should put a bandage, breathable and does not use a seal, oilcloth bandages.
In cases of fungal superinfection requires additional use of an antifungal drug. Children. Children are allowed use of the drug with two years only on strict conditions and under the supervision of a physician.due to the fact that the children area of the skin in relation to body weight is greater and underdeveloped epidermis with topical drug absorption may proportionally larger amounts of the active ingredients and, therefore, there is a greater risk of systemic side effects. Apply the medication in children should be as soon as possible and in compliance with all precautionary measures.
Effects on ability to drive vehicles and mechanisms of
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An antagonist of H 1 of the inner ear vascular histamine receptor antagonist H 3 histamine receptors of the vestibular nuclei of the central nervous system (CNS). Due to relaxation of precapillary sphincters of the inner ear blood vessels improves blood circulation in the vascular strip of the inner ear. Dose-dependently reduced the generation of action potentials in the neurons of the lateral and medial vestibular nuclei. It accelerates the recovery of vestibular function after unilateral vestibular neyrektomii, accelerating and facilitating central vestibular compensation (due to antagonism with H 3 histamine receptors). It eases symptoms of the syndrome of Meniere and vestibular vertigo. Stable therapeutic effect after 14 days.
Absorbed quickly bond to plasma proteins – low, less than 5%. The maximum plasma concentration (C max ) reached after 1 hour. It is metabolized to inactive metabolites: 2-pyridylacetic acid (the main metabolite) and demetilbetagistina. Almost completely (85-90%), kidneys displayed as a metabolite of (2-peridiluksusnoy acid) for 24 hours. Elimination of dianabol for sale and demetilbetagistina kidneys slightly.Bowel displayed only a small part of dianabol for sale and its metabolites.
Indications for use:
Treatment of Meniere’s syndrome, which is characterized by dizziness (accompanied by nausea and vomiting), hearing loss and tinnitus. Symptomatic treatment of vestibular vertigo (vertigo).
Contraindications for use:
Hypersensitivity to one of the components of the drug, children under 18 years (due to lack of data), pregnancy, lactation.
Peptic ulcer and 12 duodenal ulcer (in history), feohromitsitoma, bronchial asthma.
Pregnancy and lactation:
The drug is contraindicated during pregnancy because not enough data to assess the impact of the drug on pregnant women and the fetus. During lactation the drug should not be used or at the time of treatment should stop breastfeeding.
Dosage and administration:
Inside, during a meal.
8 mg Tablets: 1-2 tablets three times a day.
16 mg tablets: 2.1 – 1 tablet 3 times daily.
24 mg tablet: 1 tablet 2 times a day.
The course of treatment is determined individually. Improvement usually noted early in therapy, a therapeutic effect is stable after two weeks of treatment and may increase for a few months of treatment.Treatment long. The duration of the drug is chosen individually.
Frequency: often – more than 1/100 and less than 1/10.
From the digestive system: often – nausea, dyspepsia.
Allergic reactions : hypersensitivity (including anaphylaxis, angioedema, rash, urticaria, angioedema).
From the digestive system: vomiting, abdomenalnaya pain, bloating.
For the skin: itching.
Symptoms: nausea, vomiting, abdominal pain, drowsiness (while taking a dose up to 640 mg); convulsions, cardiopulmonary complications (when receiving a dose of 640 mg or more in combination with other drugs (drug).
Treatment: gastric lavage, activated charcoal, symptomatic therapy.
Interaction with other drugs: Cases interaction or incompatibility with other drugs are unknown.
The therapeutic effect in some cases increases during several months of starting treatment.
Effects on ability to drive a car or other mechanical means
dianabol for sale does not have a sedative effect and does not affect the ability to drive a car or work on the machines and mechanisms.
Tablets 8, 16, 24 mg.
At 5, 7, 10, 14, 15, 20, 30 tablets in blisters of PVC film and aluminum foil printed patent.
Betagenot is a combination drug containing a synthetic glucocorticosteroid betamethasone and dianabol antibiotic of the aminoglycoside. Betagenot has anti-inflammatory and anti-allergic effect. dianabol – a broad spectrum antibiotic of the aminoglycoside, bactericidal effect. Effective against: Staphylococcus aureus (coagulase positive, coagulase and some strains producing penicillinase), Pseudomonas acruginosa, indolpolozhitelnyh and indolotritsatelnyh species Proteus, Escherichia coli, Klebsiella pneumoniae; Hemophilus influenzae, Hemophilus aegyptius, Aerobacter atrogenes, Moraxella lacunata (stick-Moraksa Aksenfeld) and types Nesseria, including Nesseria gonorrhoeas.
Betamethasone – glucocorticosteroid, it has a local anti-inflammatory, vasoconstrictor, anti-allergic effect. It stops the release of cytokines and inflammatory mediators. It reduces the metabolism of arachidonic acid, induces lipokortinov, has anti-edematous activity.
The drug penetrates into the aqueous humor, cornea, iris, ciliary body, the retina. Can exert a systemic effect only when used in higher doses or prolonged use.
Indications for use.
- Allergic processes and anterior eye infections caused by sensitive to dianabol microflora (conjunctivitis, keratitis, blepharitis, barley);
- prevention and treatment of inflammatory events in the postoperative period (cataract,
Diseases of the ear:
- Treatment of allergic otitis externa;
- infectious otitis media caused by susceptible to dianabol microflora except viral otitis;
- chronic eczematous external otitis;
- seborrheic otitis externa;
- chronic diseases of the external ear canal skin caused by Lichen simplex.
The drug is contraindicated in the following diseases and conditions:
- Hypersensitivity to betamethasone, dianabol or other ingredients;
- fungal eye;
- acute viral diseases of the eye, including acute superficial keratitis caused by Herpes simplex;
- tubercular eye disease;
- thinning or a defect of the corneal epithelium, the sclera, glaucoma;
- children’s age, the lactation period;
- fungal infections of the skin of the outer ear canal;
- ear tuberculous lesion;
- acute viral disease of the ear;
- the presence of chronic suffering or prior otitis media;
- violation of the integrity of the tympanic membrane (development of ototoxicity).
As with the rest receiving glucocorticoid and mineralocorticoid, care must be taken in cases of cardiac, renal, hepatic insufficiency, arterial hypertension, nephrolithiasis.
In addition, caution in diabetes, high myopia, open-angle glaucoma.
Dosing and Administration
The dosage is determined individually.
Eye Disorders:. Topically in the conjunctival sac 1-2 drops of the drug solution 4-6 times a day,
ear diseases: topically in the ear canal by 3-4 drops of solution every 2-3 hours. After achieving the desired effect, it is necessary to gradually reduce the multiplicity of the drug to the desired, providing control over the symptoms of the disease.
Very rarely there may be adverse reactions from the organs of vision:
- thinning or perforation of the cornea, sclera;
- increased intraocular pressure;
- posterior subcapsular cataract formation;
- secondary infection, the spread of Herpes simplex;
- burning sensation, visual field loss, acute anterior uveitis, mydriasis, accommodation paresis, ptosis (betamethasone), allergic reactions (dianabol);
From the hearing: a burning sensation, pain and tingling in the ear, dermatitis of the external auditory canal.
During the use of the drug should regularly check the intraocular pressure, the state of the lens, as long-term therapy may develop steroid glaucoma and cataracts.
If you use contact lenses need to be removed before instillation of the drug, and can be worn after 15 minutes. Since a few minutes may be reduced after instillation of the drug, you should be careful when operating machinery and driving.
Pregnancy and lactation:
Do not use during pregnancy and lactation. Running low dose t3 clen cycle trying to lose bodyfat isn’t a real hot idea imo.