dianabol review

Pharmacological properties dianabol review – atypical antipsychotic (neuroleptic), also has a stimulating, antidepressant and antiemetic effect. Antipsychotic effect due to blockade of dopamine receptors 02 and Mesocortical mesolimbic system. Antipsychotic effect seen at doses over 600 mg / day, in doses up to 600 mg / day is dominated by stimulating and antidepressant effects.
It stimulates the secretion of prolactin, has no significant impact on adrenergi Sanchez Kie, cholinergic, serotonin, histamine and GABA receptors.
Antiemetic effect due to blockade dopamine D2-receptor trigger zone of the vomiting center. Peripheral action based on the inhibition of presynaptic receptors. In gastric ulcer and duodenal ulcers, providing selective effect on the hypothalamus, suppressing arousal centers of the sympathetic nervous system and improves blood flow to the stomach, increases the secretion of mucus in the stomach; It accelerates the proliferation of granulation tissue forms a regenerated epithelium, proliferation of capillaries improves tissue.

Pharmacokinetics
After oral administration, maximum plasma concentrations are reached in 1.5-3 hours. The bioavailability of dianabol review at intake – 27%. dianabol review Plasma protein binding is less than 40%. Quickly penetrates the liver and kidneys, slowly – in brain tissue (basic amount of drug accumulated in the pituitary gland).Concentration dianabol review in the central nervous system is 2 – 5% of the concentration in plasma. dianabol review excreted in breast milk (0.1% of the daily dose).
dianabol review in the human body is not metabolized and excreted virtually unchanged through the kidneys by glomerular filtration (92%). Total clearance – 126 ml / min. The half-life (T _½ ) is about 7 hours. This value is significantly increased in patients with moderate to severe renal insufficiency (20 – 26 hours after intravenous administration). Such patients should reduce the dose of dianabol review and / or increase the interval between doses of the drug.

Indications
Betamax should be taken strictly on prescription.
As a monotherapy or in combination with other psychotropic drugs:

• acute and chronic schizophrenia;
• acute delirious state;
• Depression different etiology;
• neuroses;
• dizziness of various etiologies (vertebro-basilar insufficiency, vestibular neuritis, Ménière’s disease, traumatic brain injury, otitis media);
• migraine;
• adjuvant therapy in gastric ulcer, duodenal ulcer and irritable bowel syndrome.

 

Contraindications

• Acute poisoning with alcohol, hypnotics, narcotic analgesics;
• hypersensitivity to the drug;
• manic psychosis;
• seizures;
• Parkinson’s disease;
• pheochromocytoma;
• prolaktinzavisimye tumors (including breast cancer);
• hyperprolactinemia;
• affective disorders, aggressive behavior;
• hypertension stage 2-3;
• breastfeeding;
• children under 18 years.

Precautions

epilepsy, hypertension, dysmenorrhea, severe diseases of the heart, angina, liver failure, neuroleptic malignant syndrome, a history of glaucoma, prostatic hyperplasia, urinary retention, old age.
Care should be exercised in the appointment of dianabol review in patients with impaired renal function, as as a 95% dianabol review eliminated via the kidneys. These patients are recommended to reduce the dose of the drug (see. Section Dosage and administration ).
It should also take precautions when appointing dianabol review patients with Parkinson’s, young women with irregular menstrual cycles.

Pregnancy and lactation
During pregnancy dianabol review prescribed in cases where the doctor to weigh the risks and benefits for the pregnant woman and the fetus, decides that the use of the drug is needed. It is recommended, whenever possible, to limit the dose and duration of treatment. The drug is contraindicated during lactation.

Dosing and Administration
Is inwards in the morning (before 16:00), regardless of the meal, washed down with a small amount of liquid. Acute and chronic schizophrenia, acute delirious psychosis: initial dose of the drug Betamax depend on the clinical picture of the disease and up to 600 – 1200 mg per day, divided into several stages; . Maintenance doses – 300 – 800 mg daily maximum recommended daily dose – 1600 mg.Depression: 150 – 200 megawatts to 600 mg per day, divided into several stages. neuroses: 400-600 mg per day, divided into several stages. Dizziness: . 150 – 200 mg per day, in severe conditions the dose can be increased to 300 – 400 mg Duration of treatment should be not less than 14 days. Migraine: 100 – 300 mg per day. Adjuvant therapy in gastric ulcer and duodenal ulcer , irritable bowel syndrome: 150 Betamax mg per day in 3 divided doses, for 4-6 weeks. the doses in patients with impaired renal function: in connection with what dianabol review excreted primarily through the kidneys, it is advisable to reduce the dose of the drug Betamax and / or increase the interval between administration of individual doses, depending on the performance of creatinine clearance:

Creatinine clearance (ml / min)	Betamax drug dose relative to the standard (%)	Increasing the interval between doses of the drug Betamax
30-60	70	1.5 times
10-30	50	2 times
less than 10	thirty	ZA times

The doses for elderly patients:
an initial dose of the drug should be Betamax ¼ – ½ adult dose. When pregnancy prescribe the lowest dose and for a long time.

 

Side effects
Adverse events, developing as a result of receiving dianabol review, like adverse events caused by other psychotropic drugs, but the frequency of their development, mostly less. On the part of the endocrine system: may develop reversible hyperprolactinemia, the most common manifestations of which are galactorrhea, menstrual disorders , at least – gynecomastia, impotence and frigidity. During treatment with dianabol review may experience excessive sweating, increased body mass index. From the digestive system: dry mouth, heartburn, nausea, vomiting, constipation, increased activity of hepatic transaminases and alkaline phosphatase (ALP). On the part of the central nervous system (CNS): extrapyramidal syndrome (usually occurs at doses above 400 mg / day), tremor, early and late dyskinesia (spasmodic torticollis, oculomotor disturbances, spasm of the masticatory muscles), akathisia (disturbance of posture), insomnia, drowsiness, anxiety, irritability, agitation, sleep disturbance, headache, neuroleptic malignant syndrome (pallor, vegetative disorders, hyperthermia). With the development of hyperthermia, the drug should be discontinued! Cardio-vascular system: increased blood pressure (BP), rarely – decreased blood pressure, orthostatic hypotension, dizziness, tachycardia, prolongation of QT-yntervala, rarely, arrhythmia such as “torsade de pointes”. Allergic reactions : possible skin rash, eczematous rash, pruritus. Vision: Violations of visual acuity.

Overdose Symptoms: dyskinesia (spasm of the masticatory muscles, spasmodic torticollis), extrapyramidal disorders. In some cases – marked parkinsonism, coma. Treatment: symptomatic.Anticholinergics central action.

 

Interactions with other drugs With simultaneous use: with levodopa decreases the effectiveness of dianabol review; with antihypertensive drugs – enhanced their hypotensive effect and increased risk of orthostatic hypotension. With drugs, CNS depressants (opioids, hypnotics and anxiolytic drugs (tranquilizers), clonidine, antitussive drugs of the central action), enhanced their inhibitory effect. Sucralfate, antacids containing of Mg ²⁺ and / or A ¹³⁺ , reduce bioavailability dianabol review 20 -. 40% antagonism of dopaminergic receptor agonists (amantadine, apomorphine, bromocriptine, cabergoline, entacapone, lisuride, pergolide, piribedil, pramipexole, kinagolid, roshpshrol) and neuroleptics. When extrapyramidal syndrome, neuroleptic induced without use of dopaminergic receptor agonists and anticholinergic drugs are used. If necessary, the treatment of patients with Parkinson’s disease during treatment with agonists of dopaminergic receptors, the last dose should be gradually reduced to a total abolition (abrupt withdrawal may lead to the development of neuroleptic malignant syndrome). In an application with sultopride increased risk of developing ventricular arrhythmias (incl . atrial fibrillation) The risk of developing ventricular arrhythmias such as “torsade de pointes” is increased by concomitant use: with antiarrhythmic drugs Ia class (quinidine, gidrohinidin, disopyramide) and class III (amiodarone, sotalol, dofetil, Ibutilide), some antipsychotics (thioridazine, chlorpromazine, Levomepromazine, trifluoperazine, tsiamemazin, amisulpride, tiaprid, haloperidol, droperidol, pimozide), with drugs that cause bradycardia (diltiazem, verapamil, beta-blockers, clonidine, guanfacine, digitalis preparations, donepizil, rivastigmine, tacrine, ambenonium chloride, galantamine, pyridostigmine, still hot from previous communes); with drugs that cause hypokalemia (kaliyvyvodyaschie diuretics, some laxatives, Amphotericin B intravenously glucocorticosteroids tetrakozaktid) with others (including bepridil, cisapride, difemanil erythromycin intravenously, mizolastine, vincamine intravenously, halofantrine, pentamidine, sparfloxacin, moxifloxacin) .

Special instructions:

In the event of hyperthermia during treatment drug should be discontinued (hyperthermia is a sign of development of neuroleptic malignant syndrome).
In the appointment of the drug in patients with epilepsy before treatment is necessary to pre-clinical and electrophysiological examination, because the drug lowers the threshold for seizure activity. In simultaneous treatment with drugs that increase the risk of ventricular arrhythmias is recommended that regular monitoring of the ECG. QT-interval lengthening – a dose-dependent effect. The use of ethanol in the background of the drug is contraindicated.

Effects on ability to drive and use machines
During treatment must be careful when driving and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions. tambol? preparation h bodybuilding natural bodybuilding steroids bodybuilding and stretch marks