An antagonist of H 1 of the inner ear vascular histamine receptor antagonist H 3 histamine receptors of the vestibular nuclei of the central nervous system (CNS). Due to relaxation of precapillary sphincters of the inner ear blood vessels improves blood circulation in the vascular strip of the inner ear. Dose-dependently reduced the generation of action potentials in the neurons of the lateral and medial vestibular nuclei. It accelerates the recovery of vestibular function after unilateral vestibular neyrektomii, accelerating and facilitating central vestibular compensation (due to antagonism with H 3 histamine receptors). It eases symptoms of the syndrome of Meniere and vestibular vertigo. Stable therapeutic effect after 14 days.
Absorbed quickly bond to plasma proteins – low, less than 5%. The maximum plasma concentration (C max ) reached after 1 hour. It is metabolized to inactive metabolites: 2-pyridylacetic acid (the main metabolite) and demetilbetagistina. Almost completely (85-90%), kidneys displayed as a metabolite of (2-peridiluksusnoy acid) for 24 hours. Elimination of dianabol for sale and demetilbetagistina kidneys slightly.Bowel displayed only a small part of dianabol for sale and its metabolites.
Indications for use:
Treatment of Meniere’s syndrome, which is characterized by dizziness (accompanied by nausea and vomiting), hearing loss and tinnitus. Symptomatic treatment of vestibular vertigo (vertigo).
Contraindications for use:
Hypersensitivity to one of the components of the drug, children under 18 years (due to lack of data), pregnancy, lactation.
Peptic ulcer and 12 duodenal ulcer (in history), feohromitsitoma, bronchial asthma.
Pregnancy and lactation:
The drug is contraindicated during pregnancy because not enough data to assess the impact of the drug on pregnant women and the fetus. During lactation the drug should not be used or at the time of treatment should stop breastfeeding.
Dosage and administration:
Inside, during a meal.
8 mg Tablets: 1-2 tablets three times a day.
16 mg tablets: 2.1 – 1 tablet 3 times daily.
24 mg tablet: 1 tablet 2 times a day.
The course of treatment is determined individually. Improvement usually noted early in therapy, a therapeutic effect is stable after two weeks of treatment and may increase for a few months of treatment.Treatment long. The duration of the drug is chosen individually.
Frequency: often – more than 1/100 and less than 1/10.
From the digestive system: often – nausea, dyspepsia.
Allergic reactions : hypersensitivity (including anaphylaxis, angioedema, rash, urticaria, angioedema).
From the digestive system: vomiting, abdomenalnaya pain, bloating.
For the skin: itching.
Symptoms: nausea, vomiting, abdominal pain, drowsiness (while taking a dose up to 640 mg); convulsions, cardiopulmonary complications (when receiving a dose of 640 mg or more in combination with other drugs (drug).
Treatment: gastric lavage, activated charcoal, symptomatic therapy.
Interaction with other drugs: Cases interaction or incompatibility with other drugs are unknown.
The therapeutic effect in some cases increases during several months of starting treatment.
Effects on ability to drive a car or other mechanical means
dianabol for sale does not have a sedative effect and does not affect the ability to drive a car or work on the machines and mechanisms.
Tablets 8, 16, 24 mg.
At 5, 7, 10, 14, 15, 20, 30 tablets in blisters of PVC film and aluminum foil printed patent.