Dianabol side effects for men selective beta 1-blocker without its own sympathomimetic activity, has no membrane stabilizing action. It lowers blood plasma renin activity, reduces myocardial oxygen demand, slows the heart rate (HR) (at rest and during exercise). It has antihypertensive, antianginal and antiarrhythmic action. Blocking in low doses of beta1-adrenergic receptors of the heart, reduces the formation of catecholamines stimulated cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP), decreases intracellular calcium ion current, has a negative chrono-, Drome, BATM and inotropic effects, inhibits the conductivity and excitability. When has exceeded therapeutic doses of beta 2-adrenoceptor blocking activity. The total peripheral vascular resistance at the beginning of the drug in the first 24 hours, is increased (as a result of reciprocal increase in the activity of alpha-adrenoceptor stimulation and removal of beta2-adrenoceptor), which is 1-3 days it returns to the original and with long-term appointment – is reduced. The hypotensive effect associated with a decrease in cardiac output, sympathetic stimulation of peripheral vascular disease, decreased activity of the renin-angiotensin system (is more important for patients with initial hypersecretion of renin), restoration of sensitivity in response to the decrease in blood pressure (BP ) and the effect on the central nervous system (CNS). When hypertension effect occurs within 2-5 days, stable operation is noted after 1-2 months. Antianginal effect is due to a decrease in myocardial oxygen demand as a result of shortening of the heart rate and reduce myocardial contractility, lengthening of diastole, improving myocardial perfusion.By increasing the end-diastolic left ventricular pressure and increase the tension of muscle fibers of the ventricles can be increased oxygen demand, especially in patients with chronic heart failure. When used in high therapeutic doses, unlike non-selective beta-blocker, has a less pronounced effect on organs containing beta2-adrenergic receptors (pancreas, skeletal muscle, smooth muscle of the peripheral arteries, bronchi and uterus) and carbohydrate metabolism; It does not cause a delay of sodium ions (Na +) in the body; atherogenic action expression is not different from that of propranolol. The antiarrhythmic effect is due to the elimination of arrhythmogenic factors (tachycardia, increased activity of the sympathetic nervous system, increased cAMP levels, hypertension), decrease in the rate of spontaneous excitation of the sinus and ectopic pacemakers and slowing of the atrioventricular (AV) of (mainly antegrade and to a lesser extent, in the retrograde direction through the AV node) and on additional routes.
Absorption – 80-90%, does not affect food intake on absorption. The maximum plasma concentration observed after 1-3 hours, the connection with plasma proteins – 26-33%. Permeability through the blood brain barrier and the placental barrier – is low. 50% of the dose is metabolized in the liver with the formation of active metabolites the half-life -. 10-12 hours Approximately 98% is excreted by the kidneys, of which 50% in an unmodified form, less than 2% through the intestines (in the bile).
- Arterial hypertension;
- Ischemic heart disease: prevention of attacks of stable angina.
Contraindications : Hypersensitivity to dianabol side effects for men or other beta-blockers; shock (including cardiogenic); collapse; pulmonary edema; congestive heart failure; Chronic heart failure decompensation requiring of inotropic therapy;AV blockade II-III degree, without a pacemaker; sinoatrial block; sick sinus syndrome; bradycardia (heart rate less than 60 beats / min..); cardiomegaly (without heart failure); severe hypotension (systolic blood pressure less than 100 mmHg, especially myocardial infarction); severe bronchial asthma and chronic obstructive pulmonary disease (COPD) history; simultaneous reception of monoamine oxidase inhibitors (MAOIs) (except for MAO-B); late stages of peripheral circulation; Reynaud’s syndrome; pheochromocytoma (without simultaneous use of alpha-blockers): metabolic acidosis; age of 18 years (effectiveness and safety have been established); lactose intolerance, lactase deficiency or glucose-galactose malabsorption (lactose as part of the preparation).
Precautions Liver failure; chronic renal failure (creatinine clearance less than 20 mL / min.); myasthenia gravis; hyperthyroidism; diabetes; Prinzmetal angina, AV block of I degree; psoriasis; depression (including history); a history of allergic reactions; adherence to a strict diet; elderly age.
Pregnancy and lactation Application Bidop drug ® during pregnancy is possible only when the intended benefits of therapy for the mother outweighs the potential risk of side effects in the fetus and / or the child. There are no data on whether dianabol side effects for men into breast milk. If necessary, use during lactation should stop breastfeeding.
Dosing and Administration Inside, in the morning on an empty stomach, not liquid, once. The dose should be adjusted individually. Arterial hypertension and coronary heart disease: prevention of attacks of stable angina usually starting dose is 5 mg 1 time a day. If necessary, increase the dose to 10 mg 1 time per day. The maximum daily dose of -20 mg per day. In patients dianabol results with impaired renal function at creatinine clearance (CC) of less than 20 ml / min. or with severe liver problems, the maximum daily dose -. 10 mg . Increasing the dose in such patients should be carried out with extreme caution dose adjustment in elderly patients is not required.
Side effects Side effects observed when using the drug, classified into categories depending on their frequency of occurrence: very common > 1/10; often> 1/100, <1/10; uncommon > 1/1000, <1/100; rare > 1/10000, <1/1000; very rare <1/10000, including isolated reports. On the part of the central nervous system : rarely – fatigue, weakness, fatigue, dizziness, headache, sleep disorders, depression, anxiety, confusion, or short-term memory loss, rarely – hallucinations, myasthenia gravis “nightmarish” dream, seizures (including calves), paresthesia in the extremities (in patients with “intermittent” claudication and Raynaud’s syndrome), tremor. On the part of the organ of vision : rarely – visual disturbances, reduced secretion of tear fluid, dry and sore eyes; very rarely – conjunctivitis. On the part of the cardiovascular system : very often – sinus bradycardia, palpitations; often – marked reduction of blood pressure, the manifestation of vasospasm (strengthening of peripheral blood circulation, cooling of the lower limbs, paresthesia, Raynaud’s syndrome); rarely – orthostatic hypotension, conduction disturbances infarction, AV block (up to the development of a complete transverse blockade and heart failure), arrhythmia, weakening of the myocardial contractility, the development of chronic heart failure (swelling of ankles, feet, shortness of breath), chest pain. On the part of the digestive system : often – dryness of the oral mucosa, nausea, vomiting, abdominal pain, constipation or diarrhea; rarely – liver function abnormalities (dark urine, yellow skin or sclera, cholestasis), changes in taste, hepatitis. With the respiratory system: rarely – shortness of breath when administered at high doses (loss of selectivity) and / or in predisposed patients – laryngo and bronchospasm; seldom – nasal congestion. On the part of the endocrine system : hyperglycemia (in patients with insulin-dependent diabetes), hypoglycemia (in patients receiving insulin), hypothyroid state. Allergic reactions :. rare – pruritus, rash, urticaria For the skin : rarely – increased sweating, flushing of the skin; very rare – rash, psoriasiform skin reactions, exacerbation of psoriasis, alopecia. Laboratory findings : rarely – increased activity of “liver” transaminases (increased alanine aminotransferase, aspartate aminotransferase), hyperbilirubinemia, hypertriglyceridemia; in some cases – thrombocytopenia (unusual bleeding and hemorrhage), agranulocytosis, leukopenia. Effect on the fetus : intrauterine growth retardation, hypoglycemia, bradycardia. Other : rarely – arthralgia; rarely – the weakening of the libido, reduced potency; back pain syndrome “cancel” (increasing angina attacks, increased blood pressure).
Overdose symptoms : arrhythmia, ventricular premature beats, bradycardia, AV block, marked reduction in blood pressure, the development of chronic heart failure, cyanosis of nails and hands, shortness of breath, bronchospasm, dizziness, fainting, seizures, hypoglycemia. Treatment : gastric lavage and the appointment of absorbent ; Symptomatic therapy: which developed at AV blockade – intravenous infusion of 1-2 mg of atropine, epinephrine or staging a temporary pacemaker; with ventricular arrhythmia – lidocaine (IA class of drugs does not apply); In marked decrease in blood pressure – the patient must be dianabol for sale in the Trendelenburg position; if there are no signs of pulmonary edema – intravenous plasma-solutions, with inefficiency – the introduction of epinephrine, dopamine, dobutamine (to maintain, chronotropic, and inotropic effects and eliminate the pronounced reduction in blood pressure); heart failure – cardiac glycosides, diuretics, glucagon; in convulsions – diazepam intravenously; with bronchospasm–beta2 adrenostimulyatorov inhalation.
Interaction with other drugs allergens used for immunotherapy, or allergen extracts for skin tests increase the risk of severe systemic allergic reactions or anaphylaxis in patients receiving dianabol side effects for men.Iodine-containing X-ray contrast agent for intravenous administration increases the risk of anaphylactic reactions. Phenytoin intravenous administration, funds for inhalation anesthesia (derivatives of hydrocarbons) increase the intensity of cardiodepressive action and the likelihood of blood pressure lowering. Modifies the effectiveness of insulin and hypoglycemic agents for oral , masking the symptoms of developing hypoglycemia (tachycardia, increased blood pressure). Reduces the clearance of lidocaine and xanthine (except theophylline) and increases their concentration in the blood plasma, especially in patients with initially increased clearance of theophylline under the influence of smoking. Antihypertensive effect of weakening non-steroidal anti-inflammatory drugs (delay of sodium ions (Na +) and the blockade of prostaglandin synthesis by the kidneys), corticosteroids, and estrogens (delay of ions Na +). Cardiac glycosides, methyldopa, reserpine and guanfacine blockers “slow” calcium channel blockers (verapamil, diltiazem), amiodarone and other antiarrhythmic drugs increase the risk of developing or worsening of bradycardia, AV block, cardiac arrest and heart failure. Nifedipine can lead to a significant reduction in blood pressure. Diuretics, clonidine, sympatholytic , hydralazine and other antihypertensive drugs may lead to an excessive reduction in blood pressure. Extends the action of non-depolarizing muscle relaxants and anticoagulant effect of coumarin . tri- and tetracyclic antidepressants, antipsychotics (neuroleptics), ethanol, sedatives and hypnotics increase central nervous system depression. not recommended simultaneous application with MAO inhibitors (except MAO-B, see. “Contraindications”), due to the significant increase in the hypotensive action, a break in treatment between receiving MAO inhibitors (except MAO-B) and dianabol side effects for men must not be less than 14 days. Negidrirovannye ergot alkaloids increase the risk of peripheral circulatory disorders. Ergotamine increases the risk of peripheral circulatory disorders; rifampin shortens the half-life.
monitoring patients receiving Bidop ® , should include measurement of heart rate and blood pressure (at the beginning of treatment -. Daily, then 1 every 3-4 months) holding an electrocardiogram, determination of blood glucose concentration of diabetic patients (1 in 4 times 5 months.). In elderly patients, it is recommended to monitor renal function (1 time in 4-5 months.). It is necessary to train the patient’s heart rate calculation method and instruct on the need of medical advice in heart rate less than 50 bpm. / Min. Before treatment recommended study of respiratory function in patients with a history of bronchopulmonary history. Approximately 20% of patients with angina Beta-blockers are ineffective. The main reasons -. Marked coronary atherosclerosis with a low threshold of ischemia (.. Heart rate less than 100 beats / min) and a higher end-diastolic volume of the left ventricle, which violates the subendocardial blood flow . At the “smokers” the effectiveness of beta-blockers lower Patients who use contact lenses, must be taken into account that in the context of treatment may decrease the production of tear fluid. When used in patients with pheochromocytoma have a risk of paradoxical hypertension (if not previously reached effective alpha adrenoblockade). When thyrotoxicosis Bidop ® may mask certain clinical signs of hyperthyroidism (eg, tachycardia). Abrupt withdrawal in patients with thyrotoxicosis is contraindicated because the symptoms can increase. In diabetes may mask tachycardia caused by hypoglycemia. In contrast, nonselective beta-blockers practically no increase insulin-induced hypoglycemia and delay recovery of blood glucose to normal levels. At the same time taking clonidine its reception can be terminated only a few days after the cancellation Bidop drug ® . Increased severity of hypersensitivity reactions are possible and the lack of effect of conventional doses of epinephrine (adrenaline) with aggravated allergic history. In the case of the need for a planned surgical treatment abolition of the drug is carried out for 48 hours before general anesthesia. If the patient has taken the drug before surgery, he should choose the drug for general anesthesia with minimal negative inotropic effect. Reciprocal activation of the vagus nerve can be eliminated by intravenous administration of atropine (1-2 mg). Drugs that reduce stocks of catecholamines (including reserpine ), may enhance the effect of beta-blockers, so patients taking such drug combinations should be under constant medical supervision in order to identify pronounced reduction in blood pressure and bradycardia. patients with bronhospasticheskimi diseases can assign cardioselective blocker in case of intolerance and / or ineffectiveness of other antihypertensive means. Overdosing is dangerous development of bronchospasm. In the case of elderly patients increasing bradycardia (less than 50 u. / Min.), Pronounced reduction in blood pressure (systolic blood pressure below 100 mm Hg), AV blockade bronchospasm, ventricular arrhythmias, severe violations of the liver and kidney is necessary to reduce the dosage or discontinue treatment. It is recommended to discontinue therapy in the development of depression. Do not abruptly discontinue the treatment because of the risk of severe arrhythmias and myocardial infarction. Abolition are gradually reducing the dose for 2 weeks or more (reduce dose by 25% in 3-4 days).It is necessary to cancel prior to the study in blood and urine catecholamines and Normetanephrine vanilinmindalnoy acid; titers of antinuclear antibodies.
Effects on ability to drive vehicles and operate machinery during treatment dizziness, especially early in therapy, and therefore must be careful when driving and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Composition Tablets 5 mg, 10 mg. By 14 tablets in blister PVC / PVDC / Al. At 1.2 or 4 blisters with instruction for use in a cardboard box.
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Dianabol steroids – selective beta1-blocker without intrinsic sympathomimetic activity. It has no membrane stabilizing (local anesthetic) activity. When topically applied dianabol steroids reduces both elevated and normal intraocular pressure due to decreased production of intraocular fluid.The onset of the hypotensive effect is usually observed after 30 minutes of use of the drug, and maximum decrease in IOP occurs in about 2 h. After a single impact on the installation ophthalmotonus maintained for 12 hours. dianabol steroids, compared with other beta-blockers, do not cause a decrease in blood flow in the optic nerve. dianabol steroids causes miosis, accommodation spasm, night blindness (unlike miotikov).
dianabol steroids highly lipophilic, resulting in good penetration through the cornea into the anterior chamber of the eye, the maximum concentration (C max ) is defined in the front chamber 20 minutes after the installation. When applied topically dianobal, systemic absorption is low, the plasma concentration is below the threshold (2 ng / ml) detected. Communication with plasma proteins – 50%. The half-life (T?) -. 14-22 hours excreted by the kidneys (15% unchanged). The permeability of the blood-brain barrier (BBB) and the placental barrier – low secretion of breast milk – small.
- ocular hypertension;
- chronic open form of glaucoma;
- angle-closure glaucoma (in combination with miotikami).
- hypersensitivity to the drug;
- sinus bradycardia;
- atrioventricular block II and III degree;
- sick sinus syndrome;
- Children up to age 18 years (due to lack of efficacy and safety data).
- Diabetes, hyperthyroidism, concomitant use of oral beta-blockers, Raynaud’s syndrome, pheochromocytoma, bronchial asthma, chronic obstructive bronchitis, atrioventricular block I degree, heart failure.
Pregnancy and lactation Use of the drug during pregnancy and lactation (breastfeeding) is possible only when the intended benefits to the mother outweighs the potential risk to the fetus or child.
Dosing and Administration Locally. 1 -2 eye drops into the conjunctival sac 2 times a day. In some patients, the stabilization of intraocular pressure occurs within a few weeks, so it is recommended to control intraocular pressure within the first month of treatment buy primabol. If the desired level of intraocular pressure is not achieved during monotherapy Betoftanom should assign additional therapy.
Side effects: Local : short-term discomfort in the eyes after instillation, watery eyes; . in some cases – reduction in corneal sensitivity, redness of the eye, keratitis, photophobia, anisocoria, blurred vision, itching, a feeling of “dryness” of the eye, allergic reactions Systemic side effects are rare. On the part of the central nervous system (CNS) : dizziness, nausea, sonlivosg , insomnia, headache, depression, increased symptoms of myasthenia gravis. Since the cardiovascular system : bradycardia, cardiac conduction and heart failure. The respiratory system : dyspnea, bronchospasm, asthma, respiratory failure.
Currently, the cases of overdose were reported Betoftana. When injected into an excess amount of the drug must be the eyes flush eyes with warm water. In case of overdose beta1-blockers may occur: hypotension, bradycardia, congestive heart failure. Treatment is symptomatic.
Interaction with other drugs With simultaneous use of the drug Betoftan and adrenaline for oftalmologicheskogoprimeneniya solution in individual cases may develop mydriasis. When using Betoftan drug in combination with drugs that deplete catecholamines (such as reserpine), may be observed amplification effects such as lowering blood pressure (BP) and bradycardia. with the simultaneous use of the drug Betoftan and beta-blockers for griema inside, increases the risk of side effects (both local and systemic) due to the additive effect. caution should be exercised when co-use of the drug Betoftan and adrenergic psychotropic drugs because of possible enhance their action. When concomitant administration danabol of muscle relaxants and hypoglycemic agents strengthen their actions can be observed. In a joint application with sympathomimetics -. Strengthening their vasoconstrictor effect can be used in combination with other topical ophthalmic medications as needed. In this case, the interval between their use should be at least 10 minutes.
Cautions Betoftan contains the preservative benzalkonium chloride, which can be adsorbed soft contact lenses and have a damaging effect on the eye tissue. Therefore, patients wearing soft contact lenses, remove them before applying drops and set back no earlier than 20 minutes after instillation. To avoid contamination of the pipette, do not touch your eyes with instillation. Diabetes Mellitus: Beta-blockers should be used with caution in patients with a tendency to hypoglycemia, as these medications can mask the symptoms of acute hypoglycemia. Thyrotoxicosis: Beta-blockers may mask some of the symptoms of hyper-tireoza ( eg, tachycardia). In patients with suspected hyperthyroidism should not abruptly cancel beta-blockers, as this may cause increase in symptoms. Myasthenia : Beta-blockers can cause symptoms similar to those of myasthenia gravis (eg, diplopia, ptosis, generalized weakness). Surgery : Before elective surgery beta-blockers should be gradually (not simultaneously!) canceled 48 hours prior to general anesthesia, as during general anesthesia may reduce myocardial sensitivity to sympathetic stimulation dianabol steroids, required for the heart. Pulmonary : caution should be exercised in the appointment of beta- blockers in patients with severely reduced function of the respiratory system. Despite the fact that clinical studies have shown no effect of dianabol steroids on respiratory function, should not exclude the possibility of hypersensitivity to the drug. The risk of an anaphylactic reaction : patients taking beta-blockers, may have a history of atopy or anaphylactic reactions. In the case of repeated reactions, such patients may not be sensitive to the usual doses of adrenaline necessary for relief of anaphylaxis. In installations drug can enter the systemic circulation. Thus, there may be side effects are the same as in the intravenous and parenteral administration of beta-blockers. Betoftan has minimal effect on blood pressure and heart rate. However, caution should be exercised in the appointment of his patients with atrioventricular block I degree, or heart failure. Treatment should be discontinued at the first signs of decompensation of the cardiovascular system. Patients who after the installation of the drug is temporarily reduced the clarity of vision, it is not recommended to engage in activities that require attention and response to his recovery.
Product form Eye drops 0.5%. In 5 ml of solution in a white polymer bottle-dropper indoor polymer cap with safety ring. One dropper bottle with instructions for use in a carton box. Acheter steroide anabolisant musculation, ou acheter des steroides en france danger des steroides anabolisants.
Dianabol before and after – selective beta1-blocker without intrinsic sympathomimetic activity. It has no membrane stabilizing (local anesthetic) activity.
When topically applied dianabol before and after reduces both elevated and normal intraocular pressure, due to reduced production of intraocular fluid. The onset of the antihypertensive effect generally occurs within 30 minutes after instillation, and the maximum reduction of intraocular pressure occurs approximately 2 hours.After a single impact on the installation ophthalmotonus maintained for 12 hours. dianabol before and after, compared with other beta-blockers, do not cause a decrease in blood flow in the optic nerve.
dianabol before and after causes miosis, accommodation spasm, night blindness, the effect of “veil” before the eyes (unlike miotikov).
Pharmacokinetics dianabol before and after highly lipophilic, resulting in good penetration through the cornea into the anterior chamber, anterior chamber Cmax determined 20 minutes after instillation. When applied topically, systemic absorption is low, the plasma concentration is below the threshold (2 ng / ml) detected. Excretion mainly through the kidneys.
Reduction of intraocular pressure as monotherapy or in combination with other drugs:
– at elevated intraocular pressure,
– with open-angle glaucoma.
Individual hypersensitivity to the drug.
Sinus bradycardia, atrioventricular block II-III degree, cardiogenic shock, heart failure, heart failure, a history of sick sinus syndrome in patients with artificial pacemaker, children up to 18 years.
Thyrotoxicosis, myasthenia gravis, diabetes, Raynaud’s syndrome, pheochromocytoma, concomitant use of oral beta-blockers.
Pregnancy and breast-feeding
Data on the effect of the drug Betoptik ® C on human fertility are not available. Pregnancy should not be used during pregnancy except in cases where it is really necessary. Sufficient experience of use of the drug during pregnancy is not. According to the results of epidemiological studies, malformativnyh effects have been identified, but with oral β-blockers there is risk of delay fetal development. In addition, signs and symptoms of .beta.-blockade (such as bradycardia, hypotension, respiratory distress and hypoglycaemia) were detected in the neonatal period in cases where the .beta.-blockers adopted mother before giving birth. It is necessary to carry out careful monitoring of babies during the first days of life if the drug Betoptik ® C, used by the mother during pregnancy. Information on the reduction of systemic absorption, see. in the “dosage and Administration”. breastfeeding β-blockers are excreted in breast milk and may cause serious adverse reactions in breast-fed infants. However, it is unlikely that the application of therapeutic doses Betoptik drug ® C, a sufficient amount of the drug to be present in breast milk to cause the development of clinical symptoms of β-blockade in the newborn. Can be used for the treatment of nursing mothers prescribed by a doctor, if the expected therapeutic benefits exceed the risk development of possible side effects. Information on the reduction of systemic absorption, see. in the “Dosing and administration”.
Dosing and Administration
Locally. Before use, the vial shaken!
According 1-2 eye drops into the conjunctival sac 2 times per day.
Recommended after instillation of the preparation the lacrimal canaliculi clamped at the inner corner of the eye (1-2 minutes). To reduce the risk of systemic side effects
in some patients the intraocular stabilization pressure occurs within a few weeks, so it is recommended to control intraocular pressure within the first month of treatment.
If the desired level of intraocular pressure is not achieved during monotherapy, combination therapy should be assigned.
Violations of the organ of vision
is very common in 10% of cases there is discomfort in the eyes.
Often, in 1-10% of cases, there is a blurred vision, increased lacrimation.
Infrequently, in 0.1-1% of cases, punctate keratitis, keratitis, conjunctivitis , blepharitis, blurred vision, photophobia, eye pain, dry eye, asthenopia, blepharospasm, itching of the eye, eye discharge, crusting on the edges of the eyelids, inflammation, eye irritation, a violation of the conjunctiva, conjunctival edema, hyperemia of the eye.
Rarely, in 0.01-0.1% of the cases, there was a cataract.
The frequency is not known: redness of the eyelids.
Disorders of the nervous system
. Often, a headache
. Occasionally, syncope
is unknown frequency: dizziness
Violations of the heart
. It is not often, bradycardia, tachycardia
Frequency not known: arrhythmia
Violations by vessels
Disorders of the respiratory system, organs, thoracic and mediastinal disorders
Uncommon: asthma, dyspnea, rhinitis.
Rare: cough, rhinorrhea.
Disorders of the gastrointestinal tract
Disorders of the skin and subcutaneous tissue disorders
Rare:. Dermatitis, rash
Frequency not known: Alopecia
Violations of the genital and breast
Rare: loss of libido.
unknown frequency: Insomnia, depression.
Violations by the immune system
Frequency unknown: hypersensitivity
General disorders and administration site reactions
Frequency unknown: asthenia.
In the application of β-blockers (eye drops) were observed, and other adverse reactions, that may develop during use of the drug and Betoptik ® C:
Violations of the immune system: systemic allergic reactions, including angioedema, urticaria, local and generalized rash, pruritus, anaphylactic reaction.
Violations of the Metabolism and nutrition:
nightmares, memory loss.
Disorders of the nervous system
cerebrovascular disorders, cerebral ischemia, worsening of symptoms of signs and symptoms of myasthenia gravis, paresthesia.
Violations by the authority of
detachment choroidal after filtration surgery, decreased corneal sensitivity, corneal erosion, ptosis, diplopia.
Disturbances of cardiac
chest pain, palpitations, edema, congestive heart failure, AV block, cardiac arrest, heart failure.
Violations of the vessels:
Raynaud’s phenomenon, cold hands and feet.
Disorders of the respiratory system, organs, thoracic and mediastinal disorders
bronchospasm (predominantly in patients with bronchospastic disease in history)
Violations of the gastrointestinal
dyspepsia, diarrhea, dry mouth, abdominal pain, vomiting
Violations of the track and subcutaneous tissue
psoriazoformnaya rash or exacerbation of psoriasis
Violations of the genital and breast
General disorders and administration site reactions
When injected into an excess amount of the drug is recommended eyes flush eyes with warm water.
If accidentally taking the drug inside the symptoms of β1-blocker overdose are: bradycardia, hypotension, acute cardiac insufficiency and bronchospasm. Treatment is symptomatic and supportive.
Interaction with other drugs
Patients receiving the drug Betoptik ® C and at the same time taking other β-blockers are administered orally, the risk of adverse reactions (both system and local) may be higher due to possible additive effects. These patients should be under close medical supervision.
When concomitant administration of β-blockers for topical ophthalmic use with oral forms of calcium channel blockers, β-blockers, anti-arrhythmic drugs (including amiodarone), digitalis glycosides, parasympathomimetics, guanethidine and drugs deplete catecholamines such as reserpine, may be observed amplification effects such as lowering blood pressure and bradycardia.
in some cases, as a result of the simultaneous application of β-blockers and adrenaline (epinephrine) may develop mydriasis.
When concomitant administration of muscle relaxants and hypoglycemic agents may be a strengthening of their actions .
.beta.-blockers may impair the effect of adrenaline, used in anaphylactic reactions. It should be used with extreme caution in patients with atopy or anaphylaxis in history.
In a joint application with sympathomimetics -. Strengthening their vasoconstrictor effect
should be taken when the joint application of dianabol before and after and adrenergic psychotropic drugs as a result of the possible increase in their actions.
Can be used in combination with other, if necessary topical ophthalmic preparations. In this case, the interval between their use should be at least 10 minutes.
Diabetes: .beta.-blockers should be used with caution in patients with a tendency to spontaneous hypoglycemia and diabetics labile currents, since these drugs may mask the signs and symptoms of acute hypoglycemia. Thyrotoxicosis: .beta.-blockers may mask some of the symptoms of hyperthyroidism (eg, tachycardia). In patients with suspected hyperthyroidism should not be abruptly cancel β-blockers, as this may cause increase in symptoms. Myasthenia gravis: β-blockers may cause signs and symptoms similar to those in infants (eg, diplopia, ptosis, generalized weakness). Surgery : the anesthetist should be advised that the patient takes dianabol before and after. Before elective surgery β-blockers should be gradually (not simultaneously!) Canceled 48 hours prior to general anesthesia because during general anesthesia may reduce myocardial sensitivity to sympathetic stimulation necessary for the operation of the heart (for example, they can block the effect of systemic β-agonist adrenaline). Pulmonary: Caution should be exercised in the appointment of β-blockers in patients with severely reduced function of the respiratory system. Despite the fact that clinical studies have shown no effect of dianabol before and after on respiratory function, should not exclude the possibility of hypersensitivity to the drug. The risk of an anaphylactic reaction: patients taking β-blockers may have a history of atopy or anaphylactic reactions. In the case of repeated reactions, such patients may be sensitive to the usual doses of adrenaline needed for the relief of anaphylaxis. dianabol before and after should be used with caution in patients with severely impaired peripheral circulation (ie with Raynaud’s syndrome and pheochromocytoma). The local assignment β-blockers can enter the systemic circulation. Thus, .beta.-blockers can cause cardiovascular, pulmonary and other adverse reactions, as well as by intravenous and parenteral administration. Cases of severe respiratory and cardiovascular disorders, including the death of bronchospasm in patients with asthma and death from heart failure. Violations of the heart: in patients with cardiovascular diseases (eg, coronary heart disease, Prinzmetal angina, heart failure) and hypotension .beta.-blocker therapy should be critically assessed and considered the possibility of the treatment of other active substances. It is necessary to closely monitor for signs of worsening disease and adverse reactions in patients suffering from cardiovascular diseases. Corneal diseases: .beta.-blockers can cause dry eyes. It should be used with caution in patients with corneal diseases. Detachment of the choroid: . Described cases of detachment of the choroid with the use of drugs that prevent the formation of intraocular fluid (eg, timolol, acetazolamide) after filtration operations preparation Betoptik ® C contains the preservative benzalkonium chloride, which can cause eye irritation and discoloration of soft contact lenses. Avoid direct contact of the product with soft contact lenses. Patients who use contact lenses, the lenses before applying the drug should be removed and set them back no earlier than 15 minutes after instillation of the drug. Do not touch the tip of the dropper bottle to any surface to avoid contamination of the vial and its contents. The vial must be closed after each use.
Effects on ability to drive vehicles and management mechanisms
Patients who after instillation of the drug is temporarily reduced sharpness of vision or other visual disturbances occur, it is not recommended to engage in activities that require attention and response to its recovery.
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Pregnancy and lactation
Use of the drug Betiol ® during pregnancy and lactation is possible if the benefit to the mother outweighs the potential risk to the fetus and child.
Dosing and Administration
buy dianabol 1-3 suppository per day, but not more than 10 suppositories a day, after cleansing enema or spontaneous bowel cleansing.
dry mouth, thirst, constipation, tachycardia, mydriasis, accommodation paresis, and allergic reactions.
If overdose possible dry mouth, thirst, constipation, tachycardia, mydriasis and other temporary visual impairment, in more severe cases – psychomotor agitation, seizures, urinary retention.
Interaction with other medicinal products
are not described.
During treatment caution should be exercised when driving and occupation of other potentially hazardous activities that require high concentration of attention, psychomotor speed reactions and good vision.
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Pharmacological properties agonist H1 histamine receptors and blood vessels of the inner ear antagonist NZ- histamine receptors of the vestibular nuclei of the central nervous system.According to preclinical studies by relaxing the sphincter prekapilyarnyh vessels of the inner ear improves blood circulation in the inner ear vascular ledge. Dose-dependently reduced the generation of action potentials in the neurons of the lateral and medial vestibular nuclei. It accelerates the recovery of vestibular function after unilateral vestibular neyrektomii, accelerating and facilitating central vestibular compensation (due to antagonism with the NC-histamine receptors). It eases symptoms of the syndrome of Meniere and vertigo.
When taken orally dianabol steroid rapidly and almost completely absorbed in the gastrointestinal tract. After absorption of the drug is rapidly and almost completely metabolised to form inactive metabolite 2-pyridylacetic acid.
Before the drug at a dose of about 8-48 mg of 85% of the initial dose is found in the urine as a 2-pyridylacetic acid. Elimination of dianabol steroid kidneys or via the gut slightly. Elimination rate constant remains dianabol steroid after oral administration 8-48 mg, ukazshaya dianabol steroid pharmacokinetic linearity, and suggests that the metabolic pathway involved remains unsaturated. When taken with food preparation dianabol steroid maximum concentration is lower than in the fasting state. However, the total absorption of dianabol steroid same in both cases, indicating that ingestion of only slows down the absorption of dianabol steroid.
Ménière’s syndrome, characterized by the following main symptoms:
- dizziness (accompanied by nausea / vomiting)
- hearing loss (deafness)
- noise in ears
Symptomatic treatment of vestibular vertigo (vertigo).
- hypersensitivity to any component of the drug.
Betaserk ® is not recommended for use in children under the age of 18 years due to lack of efficacy and safety data.
Application of pregnancy and during breastfeeding
The available data on the use of dianabol steroid in pregnant women is not enough.
The potential risk for humans is unknown. The use of dianabol steroid during pregnancy is permitted if the benefits from the use of the mother outweighs the potential risk to the fetus.
It is not known whether dianabol steroid is excreted in breast milk. Do not take the medication during breastfeeding. The appointment of a medicinal drug to the mother should be taken only after a comparison of the benefits of breastfeeding to the potential risk to the infant.
in the treatment of patients with gastric ulcer and 12 duodenal ulcer history. Patients with pheochromocytoma and asthma during treatment should be monitored regularly by a doctor.
Dosing and Administration
Always take Betaserk ® exactly as your doctor has prescribed. If you have any questions, consult your doctor.
Inside, during a meal.
Dose for adults is 48 mg per day of dianabol steroid.
Betaserk ® 24 mg should take 1 tablet 2 times a day. The tablet can be divided into two equal parts, as shown in Fig.
Place the tablet on a hard surface and push the notch up his thumb on it.
The dose should be individualized depending on the response to treatment. The improvement sometimes seen in just a few weeks of treatment. The best results are obtained sometimes after several months of treatment. There is evidence that the appointment of treatment early in the disease to prevent its progression and / or hearing loss in later stages. Correction of the dose in elderly patients and in patients with renal and / or hepatic impairment is not required.
If you notice any side effects not listed in this manual, or any side effect has taken serious, report, please your doctor.
Gastrointestinal disorders: Most (by> 1/100 to <1/10): nausea and dyspepsia. In addition to these effects identified in clinical trials, during post-marketing use and in scientific literature reported the following adverse effects. Available data are insufficient to estimate their frequency.
Immune system: hypersensitivity reactions, including anaphylaxis reported.
From the gastrointestinal tract: moderate disorders, such as vomiting, pain in the gastrointestinal tract, bloating. Typically, these effects usually disappear after dosing with food or after a dose reduction.
Skin and subcutaneous tissue: Hypersensitivity reactions such as angioneurotic edema, urticaria, pruritus and rash.
Several cases of overdose. Some patients experienced light to moderate symptoms (nausea, drowsiness, abdominal pain) after taking the drug at doses up to 640 mg. More serious complications (spasm, cardiopulmonary complications) were observed at higher doses deliberate dianabol steroid, especially in combination with other drugs overdose. Recommended symptomatic treatment.
Interaction with other medicines
If you are currently or in the recent past, you are taking other medicines, including those without a doctor’s prescription, report it, please your doctor. Studies in vivo, aimed at studying the interactions with other drugs have not been conducted. These in vitro studies suggest no activity inhibiting cytochrome P450 isozymes in vivo.
Effects on ability to drive car and other machines.
It is believed that the effect of betagietina on ability to drive and other mechanisms is absent or negligible, as in clinical trials involving the use of betagietina, effects, potentially influencing this ability were found.
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