The properties of the drug Betaderm ® due to the combined effect of dianabol cycle and gentamicin.
dianabol cycle is a synthetic fluorinated derivatives of hydrocortisone, has a strong anti-inflammatory, antipruritic, anti-allergic and vasoconstrictor action. It reduces inflammation by inhibiting the production of prostaglandins and leukotrienes activity due to inhibition of phospholipase A 2 and reduce the release of arachidonic acid from phospholipids of cell membranes, and also has anti-allergic action. Due to the local vasoconstrictor action reduces exudative reaction.Accelerates protein biotransformation in the skin and weakens the proliferative processes.
Gentamicin belongs to the antibiotic of the aminoglycoside group, is active in respect of Streptococcus spp . (Group A – ß-hemolytic and alpha-hemolytic), of Staphylococcus spp . (Staphylococcus aureus – coagulase and coagulase and some strains producing penicillinase), Gram negative bacteria: Escherichia coli, Proteus spp., Pseudomonas aeruginosa and bacteria from the group of Klebsiella spp., Enter obacter spp., Serratia spp., Citrobacter spp., Salmonella spp. and Shigella spp.
Pharmacokinetics Absorption dianabol cycle easily penetrates the skin through the stratum corneum. Not biotransformation in the skin and penetrates therethrough into the body. dianabol cycle absorption through the skin is increased when applied to the skin in the area of soft folds when applying on the skin with a damaged epidermis or skin damaged by inflammation. Moreover, absorption is increased by the frequent use of a drug or after the application over a large surface of skin. Gentamicin after topical application to unbroken skin is not absorbed, and after application to the skin damaged by the pathological process, can be absorbed into the bloodstream. Metabolism dianabol cycle biotransformed principally in . hepatic excretion dianabol cycle as compounds with glucuronic acid and a small amount of unaltered mainly eliminated via the kidneys and in smaller amounts – in bile. Gentamicin not biotransformed in the body and excreted by the kidneys unchanged.
weeping, inflammatory condition of the skin (dermatitis), complicated by secondary bacterial infection occurring and with hyperkeratosis, pruritus:
- atopic dermatitis;
- seborrheic dermatitis;
- chronic simple lichen;
- allergic contact dermatitis;
- lupus erythematosus (skin manifestations);
- erythema multiforme.
- Hypersensitivity to the drug;
- viral and fungal infections of the skin;
- cutaneous manifestations of syphilis;
- pink and acne vulgaris;
- phlebitis and trophic ulcers;
- between vaccination and post-vaccination skin reactions;
- Children under 2 years old;
Precautions : atrophy of subcutaneous tissue in the elderly.
Pregnancy and lactation
Do not use in pregnant women. At the time of treatment should stop breastfeeding.
Dosage and administration:
Outwardly. Apply a small amount of the drug to the affected surface of the skin 1-2 times a day. Continuous use of the drug for a week should not exceed 45 g. duration of treatment depends on the efficacy and tolerability, and is usually no more than 2-4 weeks.
Very rarely when using the drug Betaderm ® observed: burning sensation, erythema, exudation, pigmentation disorders and itchy.
There may be: acne, steroid purpura, inhibition of epidermal growth, atrophy of subcutaneous fat, dry skin, depigmentation or hyperpigmentation of the skin, skin atrophy and striae, telangiectasia, folliculitis.Sometimes it may appear urticaria or maculopapular rash.
Prolonged use or when applied to large surface possible systemic side effects characteristic of glucocorticosteroids (suppression of adrenocortical function, weight gain, osteoporosis, high blood pressure, edema, ulceration of the mucous membrane of the gastrointestinal intestinal tract, exacerbation of latent foci of infection, hyperkalemia, agitation, insomnia, menstrual disorders).
after application on the facial skin, the drug may cause perioral dermatitis, and after application to the skin age can sometimes cause increasing incidence of glaucoma or accelerate the development of cataracts. Moreover, given the content of gentamicin ototoxicity symptoms may occur when the drug is applied to the mucous membranes or substantial surface of the skin, particularly the damaged pathological process.
In children (side effects are in addition to side effects in adults) – inhibition of the hypothalamic-pituitary -nadpochechnikovoy system, Cushing’s syndrome, growth retardation, retarded weight gain, increased intracranial pressure (dianabol cycle).
Overdose is rarely observed. However, with prolonged use, and the use of local corticosteroids over a large surface possible adrenal suppression with the development of secondary adrenal insufficiency and Cushing’s symptoms, including Cushing’s syndrome. An overdose of gentamicin may lead to an increase in non-sensitive flora. Treatment: Symptomatic. Acute symptoms of Cushing’s usually reversible.Electrolyte balance correction is performed, if necessary.
Interaction with other drugs
The drug may increase the effects of immunosuppressive agents, and weaken the effect of immunostimulatory drugs.
is necessary to avoid long-term use, as this increases the frequency of occurrence of side effects and may develop bacterial resistance to gentamicin.
Do not use the drug on the skin of a person in connection with the appearance of telangiectasia, even after a short use.
Avoid contact Betaderm drug ® in eyes and periorbital region.
Some areas of the body (inguinal folds, armpits and perianal region) are more exposed to risk of stretch marks. Therefore, the duration of the drug should be limited to these areas.
With prolonged use Betaderm drug ® on large areas of skin with impaired integrity there is a potential absorption of gentamicin and, accordingly, the development of the symptoms of ototoxicity.
Do not use the drug under an occlusive dressing.
If there is an urgent need for overlay bandages, you should put a bandage, breathable and does not use a seal, oilcloth bandages.
In cases of fungal superinfection requires additional use of an antifungal drug. Children. Children are allowed use of the drug with two years only on strict conditions and under the supervision of a physician.due to the fact that the children area of the skin in relation to body weight is greater and underdeveloped epidermis with topical drug absorption may proportionally larger amounts of the active ingredients and, therefore, there is a greater risk of systemic side effects. Apply the medication in children should be as soon as possible and in compliance with all precautionary measures.
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